Handgrip strength and all-cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study.

ABSTRACT:

Background

This study aimed to investigate the associations of grip strength with incidence and mortality from dementia and whether these associations differ by sociodemographic and lifestyle factors.

Methods

A total of 466 788 participants of the UK Biobank (median age 56.5 years, 54.5% women). The outcome was all-cause dementia incidence and mortality and the exposure was grip strength. Grip strength was assessed using a Jamar J00105 hydraulic hand dynamometer.

Results

Excluding the first 2 years of follow-up (landmark analysis), mean follow-up was 9.1 years (inter-quartile range: 8.3; 9.7) for incidence and 9.3 (inter-quartile range: 8.7; 10.0) for mortality. During this time, 4087 participants developed dementia, and 1309 died from it. Lower grip strength was asso

SUBMITTER: Esteban-Cornejo I 

PROVIDER: S-EPMC9178163 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature