Improving Glucocorticoid Sensitivity of Brain-Homing CD4⁺ T Helper Cells by Steroid Hormone Crosstalk.

ABSTRACT: In early multiple sclerosis (MS), an IFN-γ^highGM-CSF^highIL-17^low CD4⁺ T-cell subset termed T helper 17.1 (Th17.1) reveals enhanced capacity to infiltrate the central nervous system. Th17.1 cells express high levels of multidrug resistance protein 1 (MDR1), which contributes to their poor glucocorticoid responsiveness. In this study, we explored whether glucocorticoid sensitivity of Th17.1 cells can generically be improved through synergy between steroid hormones, including calcitriol (1,25(OH)₂D₃), estradiol (E2) and progesterone (P4). We showed that human blood Th17.1 cells were less sensitive to 1,25(OH)₂D₃ than Th17 cells, as reflected by lower vitamin D receptor (VDR) levels and reduced modul

SUBMITTER: Koetzier SC 

PROVIDER: S-EPMC9178273 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature