Three-year quantitative magnetic resonance imaging and phosphorus magnetic resonance spectroscopy study in lower limb muscle in dysferlinopathy.

ABSTRACT:

Background

Natural history studies in neuromuscular disorders are vital to understand the disease evolution and to find sensitive outcome measures. We performed a longitudinal assessment of quantitative magnetic resonance imaging (MRI) and phosphorus magnetic resonance spectroscopy (³¹ P MRS) outcome measures and evaluated their relationship with function in lower limb skeletal muscle of dysferlinopathy patients.

Methods

Quantitative MRI/³¹ P MRS data were obtained at 3 T in two different sites in 54 patients and 12 controls, at baseline, and three annual follow-up visits. Fat fraction (FF), contractile cross-sectional area (cCSA), and muscle water T₂ in both global leg and thigh segments and individual muscles and ³¹ P MRS indices

SUBMITTER: Reyngoudt H 

PROVIDER: S-EPMC9178361 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature