Mitochondrially-Targeted Therapeutic Strategies for Alzheimer's Disease.

ABSTRACT: Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative disease and the most common cause of dementia among older adults. There are no effective treatments available for the disease, and it is associated with great societal concern because of the substantial costs of providing care to its sufferers, whose numbers will increase as populations age. While multiple causes have been proposed to be significant contributors to the onset of sporadic AD, increased age is a unifying risk factor. In addition to amyloid-β (Aβ) and tau protein playing a key role in the initiation and progression of AD, impaired mitochondrial bioenergetics and dynamics are likely major etiological factors in AD pathogenesis and have many potential origins, including Aβ and tau. Mitochondrial dysfuncti

SUBMITTER: Onyango IG 

PROVIDER: S-EPMC9178515 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature