Recombinant ACE2 protein protects against acute lung injury induced by SARS-CoV-2 spike RBD protein.

ABSTRACT:

Background

SARS-CoV-2 infection leads to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Both clinical data and animal experiments suggest that the renin-angiotensin system (RAS) is involved in the pathogenesis of SARS-CoV-2-induced ALI. Angiotensin-converting enzyme 2 (ACE2) is the functional receptor for SARS-CoV-2 and a crucial negative regulator of RAS. Recombinant ACE2 protein (rACE2) has been demonstrated to play protective role against SARS-CoV and avian influenza-induced ALI, and more relevant, rACE2 inhibits SARS-CoV-2 proliferation in vitro. However, whether rACE2 protects against SARS-CoV-2-induced ALI in animal models and the underlying mechanisms have yet to be elucidated.

Methods and results

Here, we demonstrated that the SARS-CoV-2 spik

SUBMITTER: Zhang L 

PROVIDER: S-EPMC9178547 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature