Microbial-Catalyzed Baeyer-Villiger Oxidation for 3,4-seco-Triterpenoids as Potential HMGB1 Inhibitors.

ABSTRACT: Pentacyclic triterpenoids are considered to be the potential HMGB1 inhibitors, but due to the limited number of hydrogen bond donors and the number of rotatable bonds in the rigid skeletons, their further chemical biology research with this target was restricted. To improve these profiles, microbial-catalyzed Baeyer-Villiger oxidation of the primary ursane and oleanane-type triterpenoids including uvaol (1), erythrodiol (2), oleanolic acid (3), and ursolic acid (4) was performed by Streptomyces olivaceus CICC 23628. As a result, ten new and one known A-ring cleaved metabolites were obtained and the possible biogenetic pathways were also discussed based on the HPLC-MS analysis. Furthermore, the direct interactions between compounds 1d, 2b, an

SUBMITTER: Shen P 

PROVIDER: S-EPMC9178611 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature