Crosslinked Chitosan-Gelatin Biocompatible Nanocomposite as a Neuro Drug Carrier.

ABSTRACT: The polymers, chitosan, a polysaccharide, and gelatin, a protein, are crosslinked in different ratios without the aid of a crosslinking agent. Facile chemical reactions were followed to synthesize a chitosan/gelatin nanocomposite in three different ratios (1:1, 1:3, and 3:1). The solubility of chitosan and the stability of gelatin were improved due to the crosslinking. Both the polymers have excellent biodegradability, biocompatibility, adhesion, and absorption properties in a biological environment. The properties of the composite were favorable to be used in drug delivery applications, and the drug dopamine was encapsulated in the composite for all three ratios. The properties of the chitosan/gelatin nanocomposite and dopamine-loaded chitosan/gelatin nanocomposite were examined using XRD

SUBMITTER: Mathew SA 

PROVIDER: S-EPMC9178715 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature