Unveiling the Possible Oryzalin-Binding Site in the α-Tubulin of Toxoplasma gondii.

ABSTRACT: Dinitroaniline derivatives have been widely used as herbicidal agents to control weeds and grass. Previous studies demonstrated that these compounds also exhibit good antiparasitic activity against some protozoan parasites. Oryzalin (ORY), a representative dinitroaniline derivative, exerts its antiprotozoal activity against Toxoplasma gondii by inhibiting the microtubule polymerization process. Moreover, the identification of ORY-resistant T. gondii lines obtained by chemical mutagenesis confirmed that this compound binds selectively to α-tubulin. Based on experimental information reported so far and a multiple sequence analysis carried out in this work, we propose that the pironetin (PIR) site is the potential ORY-binding site. Therefore, we employed state-of-the-art computa

SUBMITTER: Aguayo-Ortiz R 

PROVIDER: S-EPMC9178734 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature