CBX2 shapes chromatin accessibility promoting AML via p38 MAPK signaling pathway.

ABSTRACT:

Background

The dynamic epigenome and proteins specialized in the interpretation of epigenetic marks critically contribute to leukemic pathogenesis but also offer alternative therapeutic avenues. Targeting newly discovered chromatin readers involved in leukemogenesis may thus provide new anticancer strategies. Accumulating evidence suggests that the PRC1 complex member CBX2 is overexpressed in solid tumors and promotes cancer cell survival. However, its role in leukemia is still unclear.

Methods

We exploited reverse genetic approaches to investigate the role of CBX2 in human leukemic cell lines and ex vivo samples. We also analyzed phenotypic effects following CBX2 silencing using cellular and molecular assays and related functional mechanisms by ATAC-seq and RNA-seq. We then

SUBMITTER: Del Gaudio N 

PROVIDER: S-EPMC9178829 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature