Longitudinal evaluation of neuroinflammation and oxidative stress in a mouse model of Alzheimer disease using positron emission tomography.

ABSTRACT:

Background

Validation of new biomarkers of Alzheimer disease (AD) is crucial for the successful development and implementation of treatment strategies. Additional to traditional AT(N) biomarkers, neuroinflammation biomarkers, such as translocator protein (TSPO) and cystine/glutamine antiporter system (x_c^-), could be considered when assessing AD progression. Herein, we report the longitudinal investigation of [¹⁸F]DPA-714 and [¹⁸F]FSPG for their ability to detect TSPO and x_c^- biomarkers, respectively, in the 5xFAD mouse model for AD.

Methods

Expression of TSPO and x_c^- system was assessed longitudinally (2-12 months of age) on 5xFAD mice and their respective controls by positron emission to

SUBMITTER: Rejc L 

PROVIDER: S-EPMC9178858 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature