Ontology highlight
ABSTRACT:
SUBMITTER: Jing Z
PROVIDER: S-EPMC9178878 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Jing Zhixin Z McCarron Mark J MJ Dustin Michael L ML Fooksman David R DR
Cell reports 20220501 5
T follicular helper (TFH) cells promote expansion of germinal center (GC) B cells and plasma cell differentiation. Whether cognate peptide-MHCII (pMHCII) density instructs selection and cell fate decisions in a quantitative manner remains unclear. Using αDEC205-OVA to differentially deliver OVA peptides to GC B cells on the basis of DEC205 allelic copy number, we find DEC205<sup>+/+</sup> B cells take up 2-fold more antigen than DEC205<sup>+/-</sup> cells, leading to proportional TFH cell help a ...[more]