Clinical trials of cell therapy for heart failure: recent results warrant continued research.

ABSTRACT:

Purpose of review

Clinical trials of adult cell therapy for chronic heart failure are often misrepresented in an unfairly negative light. Results are claimed to be 'negative', 'incremental', or 'modest'. This common misconception is detrimental to medical progress and needs to be dispelled.

Recent findings

Contrary to the false narrative of scientific and lay media, the outcome of recent trials of cell therapy for heart failure has been encouraging and even exciting. Specifically, with the exception of ALLSTAR, in the past 2 years several Phase II-III double-blind, randomized trials have yielded impressive results, demonstrating not just safety but also salubrious effects on cardiac function (MSC-HF) or clinical events (MSC-HF, CONCERT-HF, and DREAM-HF) for at least 1 year a

SUBMITTER: Bolli R 

PROVIDER: S-EPMC9178910 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature