Hypertrophic Cardiomyopathy Mutations of Troponin Reveal Details of Striated Muscle Regulation.

ABSTRACT: Striated muscle contraction is inhibited by the actin associated proteins tropomyosin, troponin T, troponin I and troponin C. Binding of Ca²⁺ to troponin C relieves this inhibition by changing contacts among the regulatory components and ultimately repositioning tropomyosin on the actin filament creating a state that is permissive for contraction. Several lines of evidence suggest that there are three possible positions of tropomyosin on actin commonly called Blocked, Closed/Calcium and Open or Myosin states. These states are thought to correlate with different functional states of the contractile system: inactive-Ca²⁺-free, inactive-Ca²⁺-bound and active. The inactive-Ca²⁺-free state is highly occupied at low free Ca²⁺ levels. However

SUBMITTER: Chalovich JM 

PROVIDER: S-EPMC9178916 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature