Genetic variants associated with the occurrence and progression of adolescent idiopathic scoliosis: a systematic review protocol.

ABSTRACT:

Background

Adolescent idiopathic scoliosis (AIS) is a structural lateral spinal curvature of ≥ 10° with rotation. Approximately 2-3% of children in most populations are affected with AIS, and this condition is responsible for approximately $1.1 billion in surgical costs to the US healthcare system. Although a genetic factor for AIS has been demonstrated for decades, with multiple potentially contributory loci identified across populations, treatment options have remained limited to bracing and surgery.

Methods

The databases MEDLINE (via PubMed), Embase, Google Scholar, and Ovid MEDLINE will be searched and limited to articles in English. We will conduct title and abstract, full-text, and data extraction screening through Covidence, followed by data transfer to a custom REDCa

SUBMITTER: Terhune EA 

PROVIDER: S-EPMC9178937 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature