Morphometric similarity deviations in stimulant use disorder point towards abnormal brain ageing.

ABSTRACT: Chronic drug use negatively impacts ageing, resulting in diminished health and quality of life. However, little is known about biomarkers of abnormal ageing in stimulant drug users. Using morphometric similarity network mapping, a novel approach to structural connectomics, we first mapped cross-sectional morphometric similarity trajectories of ageing in the publicly available Rockland Sample (20-80 years of age, n = 665). We then compared morphometric similarity and neuropsychological function between non-treatment-seeking, actively using patients with stimulant use disorder (n = 183, mean age: 35.6 years) and healthy control participants (n = 148, mean age: 36.0 years). The significantly altered mean regional morphometric similarity was found in 43 cortical regions in

SUBMITTER: Zhukovsky P 

PROVIDER: S-EPMC9178962 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature