In vivo myelin imaging and tissue microstructure in white matter hyperintensities and perilesional white matter.

ABSTRACT: White matter hyperintensities negatively impact white matter structure and relate to cognitive decline in aging. Diffusion tensor imaging detects changes to white matter microstructure, both within the white matter hyperintensity and extending into surrounding (perilesional) normal-appearing white matter. However, diffusion tensor imaging markers are not specific to tissue components, complicating the interpretation of previous microstructural findings. Myelin water imaging is a novel imaging technique that provides specific markers of myelin content (myelin water fraction) and interstitial fluid (geometric mean T₂). Here we combined diffusion tensor imaging and myelin water imaging to examine tissue characteristics in white matter hyperintensities and perilesional white matter

SUBMITTER: Ferris JK 

PROVIDER: S-EPMC9178967 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature