Association of Esophageal Squamous Cell Carcinoma With the Interaction Between Poor Oral Health and Single Nucleotide Polymorphisms in Regulating Cell Cycles and Angiogenesis: A Case-Control Study in High-Incidence Chinese

ABSTRACT:

Introduction

Oral health and genetic factors can independently influence the risk of developing esophageal squamous cell carcinoma (ESCC).

Objectives

The primary objective of this study was to investigate the interactive effects of oral health and genetic factors on ESCC risk.

Methods

This was a matched case-control study with 927 ESCC patients and 1701 matched controls. We selected 101 candidate single nucleotide polymorphisms (SNPs) from 59 genes that were associated with ESCC. Oral health was assessed based on tooth-brushing frequency, tooth loss, and age at the time of first tooth loss. An unconditional logistic regression model was employed in which SNP–oral health interactions were assessed as risk factors for ESCC, after adjusting for age and sex. A geneti

SUBMITTER: Zhao R 

PROVIDER: S-EPMC9179002 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature