COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records.

ABSTRACT:

Background

Updatable estimates of COVID-19 onset, progression, and trajectories underpin pandemic mitigation efforts. To identify and characterise disease trajectories, we aimed to define and validate ten COVID-19 phenotypes from nationwide linked electronic health records (EHR) using an extensible framework.

Methods

In this cohort study, we used eight linked National Health Service (NHS) datasets for people in England alive on Jan 23, 2020. Data on COVID-19 testing, vaccination, primary and secondary care records, and death registrations were collected until Nov 30, 2021. We defined ten COVID-19 phenotypes reflecting clinically relevant stages of disease severity and encompassing five categories: positive SARS-CoV-2 test, primary care diagnosis, hospital admission, ventilat

SUBMITTER: Thygesen JH 

PROVIDER: S-EPMC9179175 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature