Ontology highlight
ABSTRACT:
SUBMITTER: Buelli S
PROVIDER: S-EPMC9179250 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Buelli Simona S Locatelli Monica M Carminati Claudia Elisa CE Corna Daniela D Cerullo Domenico D Imberti Barbara B Perico Luca L Brigotti Maurizio M Abbate Mauro M Zoja Carlamaria C Benigni Ariela A Remuzzi Giuseppe G Morigi Marina M
Cells 20220526 11
Shiga toxin (Stx)-producing <i>Escherichia coli</i> is the predominant offending agent of post-diarrheal hemolytic uremic syndrome (HUS), a rare disorder of microvascular thrombosis and acute kidney injury possibly leading to long-term renal sequelae. We previously showed that C3a has a critical role in the development of glomerular damage in experimental HUS. Based on the evidence that activation of C3a/C3a receptor (C3aR) signaling induces mitochondrial dysregulation and cell injury, here we i ...[more]