Novel Pharmacological Treatment Options in Pediatric Glioblastoma-A Systematic Review.

ABSTRACT:

Background

Pediatric glioblastoma (GBM) is an aggressive central nervous system tumor in children that has dismal prognosis. Standard of care is surgery with subsequent irradiation and temozolomide. We aimed to outline currently available data on novel pharmacological treatments for pediatric GBM.

Methods

We conducted a systematic literature search in PubMed and Embase, including reports published in English from 2010 to 2021. We included randomized trials, cohort studies and case series. Phase I trials were not analyzed. We followed PRISMA guidelines, assessed the quality of the eligible reports using the Newcastle-Ottawa scale (NOS) and the RoB-2 tool and registered the protocol on PROSPERO.

Results

We included 6 out of 1122 screened reports. All six selected report

SUBMITTER: Wyss J 

PROVIDER: S-EPMC9179254 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature