Telomere as a Therapeutic Target in Dedifferentiated Liposarcoma.

ABSTRACT:

Background

Well-differentiated (WD)/dedifferentiated (DD) liposarcoma (LPS) accounts for ~60% of retroperitoneal sarcomas. WDLPS and DDLPS divergently evolve from a common precursor and are both marked by the amplification of the 12q13-q15 region, leading to the abnormal expression of MDM2, CDK4, and HMGA2 genes. DDLPS is a non-lipogenic disease associated with aggressive clinical behavior. Patients have limited therapeutic options, especially for advanced disease, and their outcome remains largely unsatisfactory. This evidence underlines the need for identifying and validating DDLPS-specific actionable targets to design novel biology-driven therapies.

Methods

Following gene expression profiling of DDLPS clinical specimens, we observed the up-regulation

SUBMITTER: Alessandrini I 

PROVIDER: S-EPMC9179266 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature