Bottom-Up Approach to the Discovery of Clinically Relevant Biomarker Genes: The Case of Colorectal Cancer.

ABSTRACT: Traditional approaches to genome-wide marker discovery often follow a common top-down strategy, where a large scale 'omics' investigation is followed by the analysis of functional pathways involved, to narrow down the list of identified putative biomarkers, and to deconvolute gene expression networks, or to obtain an insight into genetic alterations observed in cancer. We set out to investigate whether a reverse approach would allow full or partial reconstruction of the transcriptional programs and biological pathways specific to a given cancer and whether the full or substantially expanded list of putative markers could thus be identified by starting with the partial knowledge of a few disease-specific markers. To this end, we used 10 well-documented differentially expressed markers of co

SUBMITTER: Kamel F 

PROVIDER: S-EPMC9179423 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature