Regulation of Tight Junctions by Sex Hormones in Goat Mammary Epithelial Cells.

ABSTRACT: The sex hormones of estrogen and progesterone (P₄) play a vital role in mammary gland development and milk lactation in ruminants. The tight junction (TJ) between adjacent secretory epithelial cells is instrumental in establishing the mammary blood-milk barrier. However, whether estrogen and P₄ exert their effect on mammary function via regulating TJ remain unclear. Here, to clarify the role of 17-β estradiol (E₂) and P₄ in the regulation of TJ in goat mammary gland, we first explored the relationships between the concentrations of E₂, P₄, and the protein expression of claudin-1, claudin-3, occludin, and ZO-1 during the mammary gland development in goat. Then, we further explored the mRNA and protein expression of claudin-1,

SUBMITTER: Zhu H 

PROVIDER: S-EPMC9179430 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature