The Role of Indoleamine 2, 3-Dioxygenase 1 in Regulating Tumor Microenvironment.
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ABSTRACT:
SUBMITTER: Huang X
PROVIDER: S-EPMC9179436 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
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The Role of Indoleamine 2, 3-Dioxygenase 1 in Regulating Tumor Microenvironment.
Huang Xinting X Zhang Feng F Wang Xiaobo X Liu Ke K
Cancers 20220601 11
Indoleamine 2, 3-dioxygenase 1 (IDO1) is a rate-limiting enzyme that metabolizes an essential amino acid tryptophan (Trp) into kynurenine (Kyn), and it promotes the occurrence of immunosuppressive effects by regulating the consumption of Trp and the accumulation of Kyn in the tumor microenvironment (TME). Recent studies have shown that the main cellular components of TME interact with each other through this pathway to promote the formation of tumor immunosuppressive microenvironment. Here, we r ...[more]
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