Combinatorial Therapy of Cancer: Possible Advantages of Involving Modulators of Ionic Mechanisms.

ABSTRACT: Cancer is a global health problem that 1 in 2-3 people can expect to experience during their lifetime. Several different modalities exist for cancer management, but all of these suffer from significant shortcomings in both diagnosis and therapy. Apart from developing completely new therapies, a viable way forward is to improve the efficacy of the existing modalities. One way is to combine these with each other or with other complementary approaches. An emerging latter approach is derived from ionic mechanisms, mainly ion channels and exchangers. We evaluate the evidence for this systematically for the main treatment methods: surgery, chemotherapy, radiotherapy and targeted therapies (including monoclonal antibodies, steroid hormones, tyrosine kinase inhibitors and immunotherapy). In surger

SUBMITTER: Djamgoz MBA 

PROVIDER: S-EPMC9179511 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature