Hyperammonemia syndrome in immunosuppressed individuals.

ABSTRACT:

Purpose of review

Hyperammonemia syndrome is an increasingly recognized and often fatal condition that occurs in immunosuppressed individuals, most commonly lung transplant recipients. Growing evidence suggests hyperammonemia syndrome is associated with systemic infections caused by urease-producing organisms, namely Ureaplasma spp., an organism unable to grow with routine culturing techniques. This review will summarize the epidemiology and clinical manifestations of hyperammonemia syndrome, as well as diagnostic and management strategies once hyperammonemia syndrome is suspected.

Recent findings

Hyperammonemia syndrome is being described in increasing frequency in the solid organ transplant population. Morbidity and mortality, even with treatment, is high once hyperammonem

SUBMITTER: Roberts SC 

PROVIDER: S-EPMC9179651 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature