Poloxamer 407 Induces Hypertriglyceridemia but Decreases Atherosclerosis in Ldlr^-/- Mice.

ABSTRACT:

Background

Hypertriglyceridemia (HTG) increases the risk for atherosclerotic cardiovascular disease, but underlying mechanisms are incompletely understood. Circulating monocytes play an important role in atherogenesis by infiltrating arterial walls, where they differentiate into macrophages. We tested the hypothesis that HTG is mechanistically linked to atherogenesis by altering the monocyte phenotype and infiltration into atherosclerotic lesions in a model of diet-induced atherogenesis in Ldlr^-/- mice.

Methods

HTG was induced in male Ldlr^-/- mice, fed a Western, high-fat high-cholesterol diet, by daily injection of poloxamer 407 (P407), a lipoprotein lipase inhibitor, for seven weeks. Atherosclerosis, monocyte phenotypes, and monocyte migration into at

SUBMITTER: Peng X 

PROVIDER: S-EPMC9179832 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature