Gamma Irradiation Triggers Immune Escape in Glioma-Propagating Cells

ABSTRACT:

Simple Summary

Stem cell-like glioma-propagating cells (GPCs) are crucial for initiation, growth, and treatment resistance of glioblastoma multiforme. Due to their strong immunosuppressive activities, they essentially limit immunotherapeutic approaches. This study offers a new model of radio-selected patient-derived GPCs mimicking a clinical treatment regime of tumor irradiation which is especially useful for immunotherapeutic studies. We provide evidence that clinically relevant, sub-lethal fractions of γ radiation select for a more radio-resistant GPC phenotype with lower immunogenic potential, potentially hampering the success of adjuvant T-cell-based immunotherapies. The immune evasion in GPCs was characterized by quantitative proteomics. It revealed a marked downregulation of

SUBMITTER: Hoppmann N 

PROVIDER: S-EPMC9179833 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature