Loco-Regional Therapies in Oligometastatic Adrenocortical Carcinoma.

ABSTRACT:

Objective

The recommended first-line treatment for low-tumor-burden ACC (stage IVa ACC) not amenable to radical resection is mitotane in association with loco-regional treatments (LRs). The aim of this study was to determine the patient population that would benefit the most from LR.

Materials and methods

This retrospective monocentric expert center chart review study was performed from 2008 to 2021 and included stage IVa patients (≤2 tumoral organs) treated with LR (either radiotherapy, surgery, or interventional radiology). The primary endpoint was disease control (DC). Correlations between DC, time to systemic chemotherapy (TTC), overall survival (OS), and tumor characteristics were analyzed using Kaplan-Meier survival analysis and Cox's proportional hazards regression mo

SUBMITTER: Roux C 

PROVIDER: S-EPMC9179919 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature