O-GlcNAcylation: The Underestimated Emerging Regulators of Skeletal Muscle Physiology.

ABSTRACT: O-GlcNAcylation is a highly dynamic, reversible and atypical glycosylation that regulates the activity, biological function, stability, sublocation and interaction of target proteins. O-GlcNAcylation receives and coordinates different signal inputs as an intracellular integrator similar to the nutrient sensor and stress receptor, which target multiple substrates with spatio-temporal analysis specifically to maintain cellular homeostasis and normal physiological functions. Our review gives a brief description of O-GlcNAcylation and its only two processing enzymes and HBP flux, which will help to better understand its physiological characteristics of sensing nutrition and environmental cues. This nutritional and stress-sensitive properties of O-GlcNAcylation allow

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9180116 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature