Metabolic Profiling of Mice with Deletion of the Orphan G Protein-Coupled Receptor, GPR37L1.

ABSTRACT: Understanding the neurogenic causes of obesity may reveal novel drug targets to counter the obesity crisis and associated sequelae. Here, we investigate whether the deletion of GPR37L1, an astrocyte-specific orphan G protein-coupled receptor, affects whole-body energy homeostasis in mice. We subjected male Gpr37l1^-/- mice and littermate wildtype (Gpr37l1^+/+, C57BL/6J background) controls to either 12 weeks of high-fat diet (HFD) or chow feeding, or to 1 year of chow diet, with body composition quantified by EchoMRI, glucose handling by glucose tolerance test and metabolic rate by indirect calorimetry. Following an HFD, Gpr37l1^-/- mice had similar glucose handling, body weight and fat mass compared with wildtype controls. Interestingly,

SUBMITTER: Mouat MA 

PROVIDER: S-EPMC9180194 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature