Non-Coding RNAs in the Therapeutic Landscape of Pathological Cardiac Hypertrophy.

ABSTRACT: Cardiovascular diseases are a major health problem, and long-term survival for people diagnosed with heart failure is, still, unrealistic. Pathological cardiac hypertrophy largely contributes to morbidity and mortality, as effective therapeutic approaches are lacking. Non-coding RNAs (ncRNAs) arise as active regulators of the signaling pathways and mechanisms that govern this pathology, and their therapeutic potential has received great attention in the last decades. Preclinical studies in large animal models have been successful in ameliorating cardiac hypertrophy, and an antisense drug for the treatment of heart failure has, already, entered clinical trials. In this review, we provide an overview of the molecular mechanisms underlying cardiac hypertrophy, the involvement of ncRNAs, and t

SUBMITTER: Silva J 

PROVIDER: S-EPMC9180404 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature