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Utility of iPSC-Derived Cells for Disease Modeling, Drug Development, and Cell Therapy.

ABSTRACT: The advent of induced pluripotent stem cells (iPSCs) has advanced our understanding of the molecular mechanisms of human disease, drug discovery, and regenerative medicine. As such, the use of iPSCs in drug development and validation has shown a sharp increase in the past 15 years. Furthermore, many labs have been successful in reproducing many disease phenotypes, often difficult or impossible to capture, in commonly used cell lines or animal models. However, there still remain limitations such as the variability between iPSC lines as well as their maturity. Here, we aim to discuss the strategies in generating iPSC-derived cardiomyocytes and neurons for use in disease modeling, drug development and their use in cell therapy.

SUBMITTER: Nicholson MW

PROVIDER: S-EPMC9180434 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Utility of iPSC-Derived Cells for Disease Modeling, Drug Development, and Cell Therapy.

Nicholson Martin W MW Ting Chien-Yu CY Chan Darien Z H DZH Cheng Yu-Che YC Lee Yi-Chan YC Hsu Ching-Chuan CC Huang Ching-Ying CY Hsieh Patrick C H PCH

Cells 20220606 11

The advent of induced pluripotent stem cells (iPSCs) has advanced our understanding of the molecular mechanisms of human disease, drug discovery, and regenerative medicine. As such, the use of iPSCs in drug development and validation has shown a sharp increase in the past 15 years. Furthermore, many labs have been successful in reproducing many disease phenotypes, often difficult or impossible to capture, in commonly used cell lines or animal models. However, there still remain limitations such ...[more]

PMID: 35681550

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