Ontology highlight
ABSTRACT:
SUBMITTER: Nickel S
PROVIDER: S-EPMC9180625 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Nickel Sandra S Christ Madlen M Schmidt Sandra S Kosacka Joanna J Kühne Hagen H Roderfeld Martin M Longerich Thomas T Tietze Lysann L Bosse Ina I Hsu Mei-Ju MJ Stock Peggy P Roeb Elke E Christ Bruno B
Cells 20220602 11
Mesenchymal stromal cells (MSC) increasingly emerge as an option to ameliorate non-alcoholic steatohepatitis (NASH), a serious disease, which untreated may progress to liver cirrhosis and cancer. Before clinical translation, the mode of action of MSC needs to be established. Here, we established NASH in an immune-deficient mouse model by feeding a high fat diet. Human bone-marrow-derived MSC were delivered to the liver via intrasplenic transplantation. As verified by biochemical and image analys ...[more]