Implementation of an Alternative Method for Assessing Competing Risks: Restricted Mean Time Lost.

ABSTRACT: In clinical and epidemiologic studies, hazard ratios are often applied to compare treatment effects between 2 groups for survival data. For competing-risks data, the corresponding quantities of interest are cause-specific hazard ratios and subdistribution hazard ratios. However, they both have some limitations related to model assumptions and clinical interpretation. Therefore, we recommend restricted mean time lost (RMTL) as an alternative measure that is easy to interpret in a competing-risks framework. Based on the difference in RMTL (RMTLd), we propose a new estimator, hypothetical test, and sample-size formula. Simulation results show that estimation of the RMTLd is accurate and that the RMTLd test has robust statistical performance (both type I error and statistical power). The resul

SUBMITTER: Wu H 

PROVIDER: S-EPMC9180943 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature