Serum Proteomics in Patients with Head and Neck Cancer: Peripheral Blood Immune Response to Treatment.

ABSTRACT: In this real-world study, the aims were to prospectively evaluate the expression of inflammatory proteins in serum collected from head and neck cancer patients before and after treatment, and to assess whether there were differences in expression associated with treatment modalities. The mixed study cohort consisted of 180 patients with head and neck cancer. The most common tumor sites were the oropharynx (n = 81), the oral cavity (n = 53), and the larynx (n = 22). Blood tests for proteomics analysis were carried out before treatment, 7 weeks after the start of treatment, and 3 and 12 months after the termination of treatment. Sera were analyzed for 83 proteins using an immuno-oncology biomarker panel (Olink, Uppsala, Sweden). Patients were divided into four treatment

SUBMITTER: Astradsson T 

PROVIDER: S-EPMC9180944 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature