A Review on the Role of Bicarbonate and Proton Transporters during Sperm Capacitation in Mammals.

ABSTRACT: Alkalinization of sperm cytosol is essential for plasma membrane hyperpolarization, hyperactivation of motility, and acrosomal exocytosis during sperm capacitation in mammals. The plasma membrane of sperm cells contains different ion channels implicated in the increase of internal pH (pH_i) by favoring either bicarbonate entrance or proton efflux. Bicarbonate transporters belong to the solute carrier families 4 (SLC4) and 26 (SLC26) and are currently grouped into Na⁺/HCO₃^- transporters and Cl^-/HCO₃^- exchangers. Na⁺/HCO₃^- transporters are reported to be essential for the initial and fast entrance of HCO₃^- that triggers sperm capacitation, whereas Cl^-/

SUBMITTER: Delgado-Bermudez A 

PROVIDER: S-EPMC9180951 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature