The Role of Heparin in COVID-19: An Update after Two Years of Pandemics.

ABSTRACT: Coronavirus disease 2019 (COVID-19) is associated with an increased risk of venous thromboembolism (VTE) and coagulopathy, especially in critically ill patients. Endothelial damage induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is emerging as a crucial pathogenetic mechanism for the development of complications in an acute phase of the illness and for several postdischarge sequalae. Heparin has been shown to have a positive impact on COVID-19 due to its anticoagulant function. Moreover, several other biological actions of heparin were postulated: a potential anti-inflammatory and antiviral effect through the main protease (M^pro) and heparansulfate (HS) binding and a protection from the damage of vascular endothelial cells. In this paper, we reviewed avai

SUBMITTER: Mangiafico M 

PROVIDER: S-EPMC9180990 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature