Antiproliferative Effects of the Aptamer d(GGGT)₄ and Its Analogues with an Abasic-Site Mimic Loop on Different Cancer Cells.

ABSTRACT: In this paper, we study the T30923 antiproliferative potential and the contribution of its loop residues in six different human cancer cell lines by preparing five T30923 variants using the single residue replacement approach of loop thymidine with an abasic site mimic (S). G-rich oligonucleotides (GRO) show interesting anticancer properties because of their capability to adopt G-quadruplex structures (G4s), such as the G4 HIV-1 integrase inhibitor T30923. Considering the multi-targeted effects of G4-aptamers and the limited number of cancer cell lines tested, particularly for T30923, it should be important to find a suitable tumor line, in addition to considering that the effects also strictly depend on G4s. CD, NMR and non-denaturating polyacrylamide gel electrophoresis data clearly show

SUBMITTER: Virgilio A 

PROVIDER: S-EPMC9181107 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature