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Uncommon Polyketides from Penicillium steckii AS-324, a Marine Endozoic Fungus Isolated from Deep-Sea Coral in the Magellan Seamount.


ABSTRACT: Four unusual steckwaic acids E-H (1-4), possessing a rarely described acrylic acid unit at C-4 (1-3) or a double bond between C-12 and C-13 (4) are reported for the first time, along with four new analogues (5-8) and two known congeners (9 and 10). They were purified from the organic extract of Penicillium steckii AS-324, an endozoic fungus obtained from a deep-sea coral Acanthogorgiidae sp., which was collected from the Magellan Seamount at a depth of 1458 m. Their structures were determined by the interpretation of NMR and mass spectroscopic data. The relative and absolute configurations were determined by NOESY correlations, X-ray crystallographic analysis, and ECD calculations. All compounds were tested for their antimicrobial activities against human- and aquatic-pathogenic bacteria and plant-related pathogenic fungi.

SUBMITTER: Hu XY 

PROVIDER: S-EPMC9181172 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Uncommon Polyketides from <i>Penicillium steckii</i> AS-324, a Marine Endozoic Fungus Isolated from Deep-Sea Coral in the Magellan Seamount.

Hu Xue-Yi XY   Li Xiao-Ming XM   Wang Bin-Gui BG   Meng Ling-Hong LH  

International journal of molecular sciences 20220606 11


Four unusual steckwaic acids E-H (<b>1</b>-<b>4</b>), possessing a rarely described acrylic acid unit at C-4 (<b>1</b>-<b>3</b>) or a double bond between C-12 and C-13 (<b>4</b>) are reported for the first time, along with four new analogues (<b>5</b>-<b>8</b>) and two known congeners (<b>9</b> and <b>10</b>). They were purified from the organic extract of <i>Penicillium steckii</i> AS-324, an endozoic fungus obtained from a deep-sea coral <i>Acanthogorgiidae</i> sp., which was collected from th  ...[more]

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