Serial cardiac biomarkers for risk stratification of patients with COVID-19.

ABSTRACT:

Objectives

Several studies have demonstrated an association between elevated cardiac biomarkers and adverse outcomes in patients with COVID-19. However, the prognostic and predictive capability of a multimarker panel in a prospectively collected, diverse "all-comers" COVID-19 population has not been fully elucidated.

Design & methods

We prospectively assessed high sensitivity cardiac troponin I (hsTnI), NT-pro B-type Natriuretic Peptide (NT-proBNP), Galectin-3 (Gal-3), and procalcitonin (PCT) in 4,282 serial samples from 358 patients admitted with symptomatic, RT-PCR confirmed SARS-CoV-2 infection. Outcomes examined were 30-day in-hospital mortality and requirement for intubation within 10 days.

Results

Baseline hsTnI had the highest AUC for predicting 30-day mortalit

SUBMITTER: Tawiah K 

PROVIDER: S-EPMC9181199 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature