An Emerging Cross-Species Marker for Organismal Health: Tryptophan-Kynurenine Pathway.

ABSTRACT: Tryptophan (TRP) is an essential dietary amino acid that, unless otherwise committed to protein synthesis, undergoes metabolism via the Tryptophan-Kynurenine (TRP-KYN) pathway in vertebrate organisms. TRP and its metabolites have key roles in diverse physiological processes including cell growth and maintenance, immunity, disease states and the coordination of adaptive responses to environmental and dietary cues. Changes in TRP metabolism can alter the availability of TRP for protein and serotonin biosynthesis as well as alter levels of the immune-active KYN pathway metabolites. There is now considerable evidence which has shown that the TRP-KYN pathway can be influenced by various stressors including glucocorticoids (marker of chronic stress), infection, inflammation and oxidative stress,

SUBMITTER: Jamshed L 

PROVIDER: S-EPMC9181223 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature