Endometrial Epithelial ARID1A Is Required for Uterine Immune Homeostasis during Early Pregnancy.

ABSTRACT: A growing body of work suggests epigenetic dysregulation contributes to endometriosis pathophysiology and female infertility. The chromatin remodeling complex subunit AT-rich interaction domain 1A (ARID1A) must be properly expressed to maintain normal uterine function. Endometrial epithelial ARID1A is indispensable for pregnancy establishment in mice through regulation of endometrial gland function; however, ARID1A expression is decreased in infertile women with endometriosis. We hypothesized that ARID1A performs critical operations in the endometrial epithelium necessary for fertility besides maintaining gland function. To identify alterations in uterine gene expression resulting from loss of epithelial ARID1A, we performed RNA-sequencing analysis on pre-implantation uteri from Ltf

SUBMITTER: Marquardt RM 

PROVIDER: S-EPMC9181301 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature