Physical Activity Rewires the Human Brain against Neurodegeneration.

ABSTRACT: Physical activity may offset cognitive decline and dementia, but the molecular mechanisms by which it promotes neuroprotection remain elusive. In the absence of disease-modifying therapies, understanding the molecular effects of physical activity in the brain may be useful for identifying novel targets for disease management. Here we employed several bioinformatic methods to dissect the molecular underpinnings of physical activity in brain health. Network analysis identified 'switch genes' associated with drastic hippocampal transcriptional changes in aged cognitively intact individuals. Switch genes are key genes associated with dramatic transcriptional changes and thus may play a fundamental role in disease pathogenesis. Switch genes are associated with protein processing pathways and th

SUBMITTER: Santiago JA 

PROVIDER: S-EPMC9181322 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature