Implementation of immuno-chemoinformatics approaches to construct multi-epitope for vaccine development against Omicron and Delta SARS-CoV-2 variants.

ABSTRACT:

Background

The new coronavirus is still a life-threatening menace, because of its changing nature and capacity to produce many mutations to bypass the immune system. The vaccination is the first effective weapon against COVID-19.

Aim

The study's goal was to design a multi-epitope peptide vaccine (MEPV) for a mix of Omicron and Delta Coronavirus strains using immuno-chemoinformatics tools.

Methods

To create the vaccine epitopes, seven proteins from the Omicron and Delta coronavirus strains were selected (ORF1a, ORF3a, surface protein, membrane protein, ORF7a, ORF8, and nucleocapsid protein). Antigenicity, toxicity, and allergenicity of the epitopes were evaluated.

Results

The designed vaccine is made up of 534 amino acids that are homogeneous, antigenic, and non

SUBMITTER: Dawood AA 

PROVIDER: S-EPMC9181368 | biostudies-literature | 2022 Sep-Dec

REPOSITORIES: biostudies-literature