Multiwalled Carbon Nanotubes Induce Fibrosis and Telomere Length Alterations.

ABSTRACT: Telomere shortening can result in cellular senescence and in increased level of genome instability, which are key events in numerous of cancer types. Despite this, few studies have focused on the effect of nanomaterial exposure on telomere length as a possible mechanism involved in nanomaterial-induced carcinogenesis. In this study, effects of exposure to multiwalled carbon nanotubes (MWCNT) on telomere length were investigated in mice exposed by intrapleural injection, as well as in human lung epithelial and mesothelial cell lines. In addition, cell cycle, apoptosis, and regulation of genes involved in DNA damage repair were assessed. Exposure to MWCNT led to severe fibrosis, infiltration of inflammatory cells in pleura, and mesothelial cell hyperplasia. These histological alterations wer

SUBMITTER: Alswady-Hoff M 

PROVIDER: S-EPMC9181372 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature