Five Years of Direct Oral Anticoagulants Use in Italy: Adverse Drug Reactions from the Italian National Pharmacovigilance Network.

ABSTRACT:

Background

Direct oral anticoagulants (DOACs) are the preferred anticoagulant drugs for the prevention of atrial fibrillation (AF)-related thromboembolic complications and for the treatment and the prevention of recurrences of venous thromboembolism (VTE). The evaluation of self-reported adverse drug reactions (ADRs) available from databases of drug-regulatory agencies such as the Italian Medicines Agency (AIFA) pharmacovigilance database represents a novel aid to guide decision making.

Objective

To assess the safety profile of DOACs by analyzing ADR rates in the real-world Italian scenario.

Methods

Post-marketing surveillance data recorded by the National Pharmacovigilance Network were retrieved for the time period 2017-2021 from the AIFA online site. The following d

SUBMITTER: Lavalle C 

PROVIDER: S-EPMC9181424 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature