Efficacy of Liraglutide in Non-Diabetic Obese Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Objective

We systematically assessed the efficacy of liraglutide in non-diabetic obese adults.

Methods

Six databases were searched up to July 2021 for randomized controlled trials (RCTs) assessing liraglutide versus placebo in obese adults. Primary outcomes were body weight and body mass index (BMI). Secondary outcomes were treatment-emergent adverse events (TEAEs), hypoglycemic episodes, HbA1c, and blood pressure. Effect measures were risk ratio (RR) or mean difference (MD) with their confidence interval (95%CI). Random-effects models and inverse variance meta-analyses were used. Quality of evidence was assessed using GRADE.

Results

Twelve RCTs (n = 8249) were included. In comparison to placebo, liraglutide reduced body weight (MD -3.35 kg; 95%CI -4.65 to -2.0

SUBMITTER: Barboza JJ 

PROVIDER: S-EPMC9181568 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature