Patients' Baseline Characteristics, but Not Tocilizumab Exposure, Affect Severe Outcomes Onset in Giant Cell Arteritis: A Real-World Study.

ABSTRACT:

Objectives

Giant cell arteritis (GCA) is associated with severe outcomes such as infections and cardiovascular diseases. We describe here the impact of GCA patients' characteristics and treatment exposure on the occurrence of severe outcomes.

Methods

Data were collected retrospectively from real-world GCA patients with a minimum of six-months follow-up. We recorded severe outcomes and treatment exposure. In the survival analysis, we studied the predictive factors of severe outcomes occurrence, including treatment exposure (major glucocorticoids (GCs) exposure (>10 g of the cumulative dose) and tocilizumab (TCZ) exposure), as time-dependent covariates.

Results

Among the 77 included patients, 26% were overweight (BMI ≥ 25 kg/m²). The mean cumulative dose o

SUBMITTER: Dumain C 

PROVIDER: S-EPMC9181652 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature