The High-Throughput In Vitro CometChip Assay for the Analysis of Metal Oxide Nanomaterial Induced DNA Damage.

ABSTRACT: Metal oxide nanomaterials (MONMs) are among the most highly utilized classes of nanomaterials worldwide, though their potential to induce DNA damage in living organisms is known. High-throughput in vitro assays have the potential to greatly expedite analysis and understanding of MONM induced toxicity while minimizing the overall use of animals. In this study, the high-throughput CometChip assay was used to assess the in vitro genotoxic potential of pristine copper oxide (CuO), zinc oxide (ZnO), and titanium dioxide (TiO₂) MONMs and microparticles (MPs), as well as five coated/surface-modified TiO₂ NPs and zinc (II) chloride (ZnCl₂) and copper (II) chloride (CuCl₂) after 2-4 h of exposure. The CuO NPs, ZnO NPs and MPs, and ZnCl₂ exposur

SUBMITTER: Boyadzhiev A 

PROVIDER: S-EPMC9181865 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature